Production of prostaglandins and leukotrienes by Paracoccidioides brasiliensis
نویسندگان
چکیده
منابع مشابه
Production of prostaglandins and leukotrienes by pathogenic fungi.
These studies demonstrate that pathogenic fungi (dermatophytic, subcutaneous, and systemic) have the ability to produce eicosanoids both from simple metabolites and from arachidonic acid. Host-derived eicosanoids have been previously demonstrated to enhance fungal colonization and atopic disease development. Thus, fungus-derived eicosanoids represent a potential class of novel virulence factors.
متن کامل[Prostaglandins and leukotrienes].
Two classes of arachidonic acid derivatives can be formed by two distinct enzyme systems. Cyclo-oxygenases synthesise prostaglandins, prostacyclin and thromboxane A2 which all possess both pro- and anti-inflammatory properties. Lipoxygenases synthesise on the one hand chemotactic factors, the hydroxylated derivatives of arachidonic acid, the most powerful of which is leukotriene B4, and on the ...
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Paracoccidioides brasiliensis is the etiologic agent of paracoccidioidomycosis (PCM), the most prevalent systemic mycosis that is geographically confined to Latin America. The pro-inflammatory cytokine IL-1β that is mainly derived from the activation of the cytoplasmic multiprotein complex inflammasome is an essential host factor against opportunistic fungal infections; however, its role in inf...
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The yeastlike form of Paracoccidioides brasiliensis strain IVIC Pb9 reduced the amount of a-1,3-glucan in its cell wall from 45 to 3% when subcultured in vitro for several years. This strain regained its a-1,3-glucan up to 25% of the total cell wall when grown in vivo. A mutant strain of P. brasiliensis Pb9, named IVIC Pbl4O, reported to have 1,3-mannan instead of a-glucan in the cell wall, cou...
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To commemorate Prof. Carlos da Silva Lacaz's centennial anniversary, the authors have written a brief account of a few, out of hundreds, biological, ecological, molecular and phylogenetic studies that led to the arrival of Paracoccidioides lutzii, hidden for more than a century within Paracoccidioides brasiliensis. Lacaz's permanent interest in this fungus, and particularly his conviction on th...
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ژورنال
عنوان ژورنال: Journal of Venomous Animals and Toxins including Tropical Diseases
سال: 2009
ISSN: 1678-9199
DOI: 10.1590/s1678-91992009000100017